The most important guide on this forum is the levelling and endgame guide. Until endgame, you do the main quest, the side quests, and a little bit of filler when quests run out at a couple points.
In game, there are a ton of tutorials on all of the mechanics. There is a big red blob in the top right corner - that is your cultivation icon. You use it to start tutorials on all the life stuff - fishing, housing, all sorts of things.
The Cultivation Icon also shows you your daily and weekly events - some of which you have to do a tutorial quest first.